Plant Transcription Factor Database
Previous version: v3.0
Coffea canephora
HD-ZIP Family
Species TF ID Description
Cc07_g14600HD-ZIP family protein
Cc11_g13310HD-ZIP family protein
Cc04_g15600HD-ZIP family protein
Cc07_g02340HD-ZIP family protein
Cc08_g12040HD-ZIP family protein
Cc06_g15740HD-ZIP family protein
Cc11_g13540HD-ZIP family protein
Cc02_g27050HD-ZIP family protein
Cc02_g24900HD-ZIP family protein
Cc07_g03210HD-ZIP family protein
Cc07_g07540HD-ZIP family protein
Cc10_g07840HD-ZIP family protein
Cc10_g06690HD-ZIP family protein
Cc07_g09150HD-ZIP family protein
Cc11_g08670HD-ZIP family protein
Cc06_g12870HD-ZIP family protein
Cc06_g04990HD-ZIP family protein
Cc08_g16780HD-ZIP family protein
Cc06_g20620HD-ZIP family protein
Cc02_g14000HD-ZIP family protein
Cc04_g11990HD-ZIP family protein
Cc02_g01010HD-ZIP family protein
Cc06_g12880HD-ZIP family protein
Cc04_g03030HD-ZIP family protein
Cc02_g11560HD-ZIP family protein
Cc02_g37380HD-ZIP family protein
Cc08_g09740HD-ZIP family protein
Cc04_g08940HD-ZIP family protein
Cc09_g08040HD-ZIP family protein
Cc02_g03270HD-ZIP family protein
Cc01_g11100HD-ZIP family protein
Cc08_g03370HD-ZIP family protein
Cc07_g12840HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401